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. 2017 Jul 26;8(34):55821–55836. doi: 10.18632/oncotarget.19608

Figure 1. Identification of p53-repressed gene candidates.

Figure 1

A. Schematic of the MCF10A cells dataset screen is shown. MCF10A p53+/+ cells and MCF10A p53−/− cells were treated with 0.5 μg/ml ADR for 2 hours, then cultured with fresh medium by indicated time. Subsequently, the cells were subjected to transcriptome analysis. Red dots indicate 44 common p53-repressed gene candidates identified in (D). W: MCF10A p53+/+ cells, K: MCF10A p53−/− cells. B. Schematic of the p53 mice dataset screen is shown. p53+/+ and p53−/− female mice (10 weeks old) were irradiated at 10 Gy (total body irradiation [TBI]). Twenty-four hours after irradiation, the gene expression level in the mammary gland was analyzed using RNA-seq. Blue dots indicate 44 common p53-repressed gene candidates identified in (D). C. Schematic of the TCGA dataset (BRCA: Breast Invasive Carcinoma) screen is shown. Green dots indicate 44 common p53-repressed gene candidates identified in (D). D. Venn diagram displaying the overlap between the three datasets obtained from A., B., and C.