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. 2017 Jul 5;8(34):55984–55997. doi: 10.18632/oncotarget.18995

Figure 5. PC2 modulates the mTOR pathway under hyperosmotic stress conditions.

Figure 5

PC2 was downregulated in HeLa A.-D. and HCT116 E.-F. cells using a specific siRNA against PC2. An unrelated siRNA (UNR) was used as a control. Subsequently, cells were treated with 0, 50 or 200 mOsm sorbitol or mannitol and p-S6, S6 and PC2 levels were evaluated by Western blot analysis. Representative gels are shown in A., C. and E.. Quantification of gel bands is shown in B., D. and F. (mean ± SEM, n = 3, *p < 0.05 vs. 0 mOsm siUNR). GAPDH levels were used as a loading control.