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. 2017 Apr 21;8(34):56051–56065. doi: 10.18632/oncotarget.17359

Figure 2. CPT1A is needed to maintain viability and invasion of prostate cancer cell lines.

Figure 2

A. Western blot of CPT1A- knockdown (KD) LNCaP clones (sh-1 and sh-2). B. Increased accumulation of lipid in CPT1A-KD clones. Red stain shows lipid droplets. C. Decreased clonogenicity of CPT1A-KD clones, *p < 0.01 compared to control (NT). D. Decreased invasion of KD clones compared to controls (NT), *p < 0.01. E. Western blot of CPT1A-KO CRISPR-edited LNCaP cells (CPT1A-KO). F.-G. Representative clonogenic assay (F) and live cell photographs (G) of CPT1A-KO cells. H. Decreased invasion of CPT1A-KO cells compared to controls (CTRL), *p < 0.01. I. Decreased palmitate oxidation in CPT1A-KO cells compared to control clones, *p < 0.01.