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. 2017 May 23;8(34):56110–56125. doi: 10.18632/oncotarget.18125

Figure 6. SAHA suppressed hypoxia signaling in Hep3B cell xenografts in vivo.

Figure 6

A. In-vitro luciferase assay shows decreased HRE activity in Hep3B HRE-Luc cells in the presence of SAHA. B. Tumor growth curves of Hep3B HRE-Luc cell xenografts treated with SAHA show significantly decreased tumor size at 7- and 9-days post-implantation (p < 0.05, p < 0.01, respectively). C. Average tumor weight of excised xenografts is significantly reduced in SAHA-treated mice compared to control mice (p < 0.05) at study endpoint. D. Example luminescence of excised Hep3B HRE-Luc cell xenografts at study endpoint. E. HRE-luc luminescence is significantly decreased in SAHA treated mice compared to control (p < 0.05) at study endpoint. F., G. VEGFA and EPO expression is significantly decreased in tumors resected from SAHA treated mice at study endpoint. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.