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. 2017 Apr 20;8(34):56228–56242. doi: 10.18632/oncotarget.17280

Figure 4. HCV core induces the expression of MTA1, a 4E-BP1 downstream target.

Figure 4

(A) Immunoblotting analysis of MTA1 expression in lysates of HuH7 controls (WT), HuH7 stably expressing core protein variants either isolated from tumor or non-tumor cirrhotic (cT or cNT) areas and HuH9.13 harboring the HCV NS3-NS5B subgenomic replicon and its related control (HuH9.13 cured). (B) Liver proteins extracted from 9-month-old WT, transgenic mice that specifically express HCV core protein isolated from tumor and non-tumor (cT or cNT) areas (4 different mice per group) were analyzed for MTA1 expression by immunoblot.