Figure 6. Average tumor growth inhibition, survival analysis and body weight changes.

Start of treatment is indicated with an arrow in each plot (study day 15). (A) Average tumor growth inhibition until study day 103. Statistical analysis was performed using one-way ANOVA (Dunnett's testing) in comparison to vehicle (n.s., not significant; *, p < 0.05; **, p < 0.01; ***, p < 0.001; ****, p < 0.0001. (B) Survival plot analysis of animals sacrificed due to humane endpoint (tumor volume > 1500 mm³). Animals were either treated with vehicle, CD70 antibody-chelator conjugate, isotype control-TTC (500 kBq/kg; 0.36 mg/kg) or with CD70-TTC at the indicated doses (50, 100, 300 or 500 kBq/kg; 0.36 mg/kg). The median survival time (MST) for the vehicle control group was determined to be 86 days and the MST of the CD70 antibody-chelator conjugate was 91 days, whereas the MST for animals treated with isotype control-TTC was 113 days. The MST for groups receiving CD70-TTC could not be determined. Data were analyzed using Log-Rank (Mantel-Cox) analysis (n.s., not significant; *, p < 0.05, **, p < 0.01; ***, p < 0.001; ****, p < 0.0001). (C) Changes in body weight, expressed in %.