Table 3. List of biopsies included in this study with patient clinicopathologic parameters and immunohistochemical staining scores for ERβ and MMP-2.

Case No.	Gender	Age at time of surgery	Tumor Stage UICC	Tumor Stage TNM	Lymphnode metastasis ratio	IHC score of ERβ		IHC score of MMP2
						Primary Tumor	Lymphnode Metastasis	Primary Tumor	Lymphnode Metastasis
01	Female	48	IIIA	pT2aN2	11/13	++	++	+	+
02	Male	64	IIIA	pT2aN2	11/26	+	+++	+	-
03	Male	66	IIIA	pT2bN2	5/21	++	+++	-	-
04	Male	21	IIIA	pT2bN2	6/26	++	++	-	-
05	Male	63	IIIA	pT2bN2	4/16	++	++	++	+
06	Male	57	IIIA	pT2aN2	7/16	+	+++	+	-
07	Male	46	IIIA	pT2aN2	5/27	+++	+++	-	++
08	Female	58	IIIB	pT3N3	4/14	+	+++	+++	+
09	Male	52	IIIA	pT2aN2	5/18	++	++	-	-
10	Male	38	IIIB	pT4N2	4/16	++	++	-	-
11	Male	60	IIB	pT2bN1	2/40	+	+++	+	-
12	Male	58	IIIA	pT3N2	11/18	+++	+++	-	++
13	Male	53	IIIB	pT2bN3	14/20	++	+++	-	++
14	Female	57	IIIB	pT1bN3	9/12	+++	+++	+	+
15	Male	42	IIIA	pT2aN2	14/32	+++	+++	+	+
16	Male	72	IIIA	pT2aN2	7/11	++	+++	+	+
17	Male	64	IIB	pT2aN1	1/10	++	++	+	++
18	Male	61	IIIA	pT2bN2	2/10	+++	+++	++	++
19	Male	65	IIIB	pT4N2	1/32	+++	+++	-	+
20	Male	66	IIIA	pT2bN2	4/8	+++	++	-	++
21	Male	67	IIB	pT2aN1	2/14	++	+++	-	+
22	Male	53	IIIA	pT2aN2	11/23	+++	+++	-	+
23	Male	59	IIIA	pT2aN2	16/31	++	+++	+	-
24	Male	45	IIIB	pT2aN3	8/11	+	+++	-	+
25	Male	60	IIIA	pT3N2	9/35	+++	++	-	-
26	Male	59	IIIA	pT2aN2	7/20	++	+++	+	-
27	Male	47	IIIA	pT2aN2	12/18	++	+++	-	+
28	Male	69	IIIA	pT2bN2	2/37	+	+++	+	++
29	Male	57	IIIA	pT3N1	1/11	+	+++	-	-
30	Male	60	IIIA	pT2aN2	5/11	++	+++	-	-
ERβ primary vs. LN t value			p value			Median score	Median score
4.402			<0.001			11.10	14.57