Table 4. Tumour initiation frequency is lower in xenograft cells treated with a combination of AKT and mTOR inhibitor.
Number of inoculated cells | 10 000 cells | 1000 cells | 100 cells | 10 cells | 1 cell | Tumour initiation frequency(95% CI) |
---|---|---|---|---|---|---|
Treatment | ||||||
0.2% DMSO | 2/2 | 2/2 | 2/2 | 1/2 | 0/2 | 16.6 (98.9-3.16) |
10 γM AZD7328 | 2/2 | 2/2 | 2/2 | 0/2 | 0/2 | 43.8 (201.1-9.84) |
10 γM KU-0063794 | 2/2 | 2/2 | 2/2 | 1/2 | 0/2 | 16.6 (98.9-3.16) |
10 +10 combination | 2/2 | 2/2 | 0/2 | 0/2 | 0/2 | 434.6 (2008.4-94.36) |