Table 1. Characteristics of studies included in the meta-analysis.
Author last name | Year | Cancer type | Country | Ethnicity | Design | Genotype method | Case | Control | MAF | HWE | Score | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
II | ID | DD | All | II | ID | DD | All | ||||||||||
Sun | 2007 | Lung | China | Asian | PB | PCR-RFLP | 756 | 348 | 45 | 1149 | 640 | 407 | 64 | 1111 | 0.24 | 0.947 | 11 |
Sun | 2007 | Esophagus | China | Asian | PB | PCR-RFLP | 652 | 328 | 38 | 1018 | 543 | 338 | 56 | 937 | 0.24 | 0.724 | 11 |
Sun | 2007 | Gastric | China | Asian | PB | PCR-RFLP | 262 | 142 | 16 | 420 | 233 | 152 | 25 | 410 | 0.25 | 0.975 | 11 |
Sun | 2007 | Colorectal | China | Asian | PB | PCR-RFLP | 605 | 280 | 33 | 918 | 528 | 304 | 58 | 890 | 0.24 | 0.116 | 11 |
Sun | 2007 | Breast | China | Asian | PB | PCR-RFLP | 699 | 371 | 49 | 1119 | 513 | 419 | 72 | 1004 | 0.28 | 0.279 | 11 |
Sun | 2007 | Cervical | China | Asian | PB | PCR-RFLP | 199 | 102 | 13 | 314 | 314 | 211 | 42 | 567 | 0.26 | 0.428 | 10 |
Yang | 2008 | Pancreatic | China | Asian | PB | PCR-RFLP | 268 | 111 | 18 | 397 | 521 | 323 | 63 | 907 | 0.25 | 0.185 | 13 |
Pittman | 2008 | Colorectal | England | Caucasian | PB | AS-PCR | 995 | 1897 | 987 | 3879 | 892 | 1872 | 897 | 3661 | 0.50 | 0.170 | 9 |
Frank | 2008 | Breast | Germany | Caucasian | HB | Fluorescent | 298 | 535 | 221 | 1054 | 270 | 506 | 263 | 1039 | 0.50 | 0.403 | 7 |
Frank | 2008 | Breast | England | Caucasian | PB | Fluorescent | 235 | 541 | 251 | 1027 | 245 | 608 | 321 | 1174 | 0.53 | 0.169 | 10 |
Frank | 2008 | Breast | Germany | Caucasian | PB | Fluorescent | 280 | 509 | 222 | 1011 | 285 | 492 | 229 | 1006 | 0.47 | 0.550 | 9 |
Frank | 2008 | Breast | England | Caucasian | PB | Fluorescent | 1133 | 2115 | 1050 | 4298 | 1149 | 2263 | 1062 | 4474 | 0.49 | 0.422 | 8 |
Cybulski | 2008 | Breast | Poland | Caucasian | PB | AS-PCR | 178 | 314 | 126 | 618 | 274 | 499 | 192 | 965 | 0.46 | 0.195 | 6 |
Cybulski | 2008 | Prostate | Poland | Caucasian | PB | AS-PCR | 139 | 236 | 110 | 485 | 274 | 499 | 192 | 965 | 0.46 | 0.195 | 6 |
Li | 2008 | Melanoma | USA | Caucasian | HB | PCR | 243 | 385 | 177 | 805 | 207 | 440 | 188 | 835 | 0.49 | 0.116 | 11 |
Wang | 2009 | Bladder | China | Asian | HB | PCR-RFLP | 238 | 115 | 12 | 365 | 205 | 138 | 25 | 368 | 0.26 | 0.786 | 10 |
Gangwar | 2009 | Bladder | India | Asian | HB | PCR-RFLP | 121 | 84 | 7 | 212 | 133 | 101 | 16 | 250 | 0.27 | 0.584 | 9 |
De Vecchi | 2009 | Breast | Italy | Caucasian | PB | PCR-RFLP | 162 | 301 | 117 | 580 | 106 | 206 | 94 | 406 | 0.49 | 0.752 | 7 |
Zhu | 2010 | RCC | China | Asian | HB | PCR-RFLP | 226 | 119 | 8 | 353 | 205 | 139 | 21 | 365 | 0.25 | 0.686 | 11 |
Srivastava | 2010 | Gallbladder | India | Asian | PB | PCR-RFLP | 147 | 69 | 12 | 228 | 122 | 84 | 24 | 230 | 0.29 | 0.103 | 11 |
Liu | 2010 | Colorectal | China | Asian | PB | PCR-RFLP | 233 | 116 | 21 | 370 | 528 | 278 | 32 | 838 | 0.20 | 0.538 | 13 |
Li | 2010 | HNSCC | USA | Caucasian | HB | PCR–RFLP | 311 | 456 | 256 | 1023 | 257 | 542 | 253 | 1052 | 0.50 | 0.324 | 10 |
Xiao | 2011 | Lymphoma | China | Asian | NM | PCR-PAGE | 43 | 17 | 4 | 64 | 89 | 38 | 6 | 133 | 0.19 | 0.460 | 3 |
Xiao | 2011 | Lymphoma | China | Asian | NM | PCR-PAGE | 49 | 23 | 3 | 75 | 63 | 40 | 4 | 107 | 0.22 | 0.442 | 3 |
Umar | 2011 | Esophageal | India | Asian | PB | PCR | 139 | 103 | 17 | 259 | 138 | 93 | 28 | 259 | 0.29 | 0.046 | 11 |
Theodoropoulos | 2011 | Colorectal | Greece | Caucasian | HB | RFLP-PCR | 103 | 201 | 98 | 402 | 120 | 254 | 106 | 480 | 0.49 | 0.194 | 9 |
Malik | 2011 | Esophageal | India | Asian | HB | RFLP-PCR | 68 | 59 | 8 | 135 | 96 | 75 | 24 | 195 | 0.32 | 0.127 | 8 |
Malik | 2011 | Gastric | India | Asian | HB | RFLP-PCR | 59 | 44 | 5 | 108 | 96 | 75 | 24 | 195 | 0.32 | 0.127 | 8 |
Ma | 2011 | Ovarian | China | Asian | HB | MassARRAY | 128 | 87 | 3 | 218 | 138 | 122 | 25 | 285 | 0.30 | 0.789 | 8 |
Liamarkopoulos | 2011 | Gastric | Greece | Caucasian | HB | PCR-RFLP | 35 | 42 | 11 | 88 | 120 | 254 | 106 | 480 | 0.49 | 0.194 | 7 |
Hart | 2011 | Lung | Norway | Caucasian | PB | TaqMan | 125 | 210 | 101 | 436 | 106 | 209 | 118 | 433 | 0.51 | 0.481 | 10 |
Chatterjee | 2011 | Cervical | South Africa | African | HB | PCR-RFLP | 18 | 63 | 25 | 106 | 43 | 129 | 85 | 257 | 0.58 | 0.614 | 6 |
Fu | 2011 | Prostate | China | Asian | HB | PCR-RFLP | 257 | 132 | 17 | 406 | 211 | 159 | 38 | 408 | 0.29 | 0.315 | 10 |
Wang | 2012 | RCC | China | Asian | HB | PCR-RFLP | 192 | 101 | 7 | 300 | 168 | 114 | 18 | 300 | 0.25 | 0.817 | 10 |
Wang | 2012 | PTC | China | Asian | HB | PCR–RFLP | 65 | 45 | 8 | 118 | 106 | 92 | 15 | 213 | 0.29 | 0.408 | 7 |
Tong | 2012 | ALL | China | Asian | HB | PCR-RFLP | 217 | 113 | 31 | 361 | 338 | 153 | 28 | 519 | 0.20 | 0.057 | 10 |
Hashemi | 2012 | Breast | Iran | Asian | HB | AS-PCR | 113 | 107 | 16 | 236 | 79 | 91 | 33 | 203 | 0.39 | 0.434 | 6 |
George | 2012 | Prostate | India | Asian | HB | PCR-RFLP | 84 | 69 | 12 | 165 | 116 | 83 | 6 | 205 | 0.23 | 0.050 | 9 |
Xiao | 2013 | Colorectal | China | Asian | HB | PCR-PAGE | 187 | 107 | 11 | 305 | 212 | 115 | 15 | 342 | 0.21 | 0.905 | 7 |
Wu | 2013 | Colorectal | China | Asian | HB | PCR-SSCP | 284 | 152 | 15 | 451 | 358 | 244 | 29 | 631 | 0.24 | 0.119 | 11 |
De Martino | 2013 | RCC | Austria | Caucasian | HB | PCR-RFLP | 72 | 138 | 40 | 250 | 53 | 129 | 68 | 250 | 0.53 | 0.572 | 9 |
Pardini | 2014 | Colorectal | Spain | Caucasian | PB | Taqman | 500 | 996 | 482 | 1978 | 425 | 802 | 420 | 1647 | 0.50 | 0.290 | 11 |
Pardini | 2014 | Colorectal | Italy | Caucasian | PB | Taqman | 195 | 285 | 137 | 617 | 783 | 1230 | 538 | 2551 | 0.45 | 0.178 | 9 |
Pardini | 2014 | Colorectal | USA | Caucasian | PB | Taqman | 237 | 514 | 259 | 1010 | 383 | 794 | 403 | 1580 | 0.51 | 0.835 | 9 |
Pardini | 2014 | Colorectal | England | Caucasian | PB | Taqman | 410 | 825 | 341 | 1576 | 165 | 393 | 209 | 767 | 0.53 | 0.436 | 11 |
Pardini | 2014 | Colorectal | Czech | Caucasian | PB | Taqman | 239 | 479 | 249 | 967 | 169 | 326 | 177 | 672 | 0.51 | 0.443 | 10 |
Pardini | 2014 | Colorectal | Netherlands | Caucasian | PB | Taqman | 169 | 282 | 134 | 585 | 106 | 177 | 76 | 359 | 0.46 | 0.895 | 8 |
Tang | 2015 | OSCC | China | Asian | HB | PCR-RFLP | 328 | 159 | 18 | 505 | 276 | 197 | 34 | 507 | 0.26 | 0.885 | 10 |
Carvalho | 2015 | ALL | Brazil | Mixed | NM | PCR | 23 | 81 | 26 | 130 | 47 | 53 | 25 | 125 | 0.41 | 0.163 | 4 |
MAF: minor allele frequency; HWE: Hardy-Weinberg equilibrium; OSCC: oral squamous cell carcinoma; PTC: papillary thyroid carcinoma; RCC: renal cell carcinoma; HNSCC: head and neck squamous cell carcinoma; ALL: acute lymphocytic leukemia; PB: population based; HB: hospital based; NM: not mentioned; PCR-PAGE: polymerase chain reaction-polyacrylamide gel electrophoresis; PCR-RFLP: polymerase chain reaction-restriction fragment length polymorphism; AS-PCR: allele-specific polymerase chain reaction.