Table 2. Meta-analysis of the association between the CASP8 -652 6N ins/del polymorphism and overall cancer risk.
Variables | No. of studies | Sample size | Homozygous | Heterozygous | Recessive | Dominant | Allele | |||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
DD vs. II | ID vs. II | DD vs. ID/II | ID/DD vs. II | D vs. I | ||||||||
OR (95% CI) | P het | OR (95% CI) | P het | OR (95% CI) | P het | OR (95% CI) | P het | OR (95% CI) | P het | |||
All | 49 | 33494/36397 | 0.76 (0.69-0.84) | <0.001 | 0.87 (0.83-0.92) | <0.001 | 0.82 (0.75-0.89) | <0.001 | 0.85 (0.80-0.90) | <0.001 | 0.87 (0.83-0.91) | <0.001 |
Cancer type | ||||||||||||
Colorectal | 12 | 13058/14418 | 0.93 (0.82-1.05) | 0.018 | 0.94 (0.88-0.99) | 0.529 | 0.96 (0.87-1.06) | 0.019 | 0.93 (0.87-1.00) | 0.190 | 0.96 (0.90-1.01) | 0.012 |
Breast | 8 | 9943/10271 | 0.80 (0.67-0.96) | 0.001 | 0.90 (0.81-1.01) | 0.018 | 0.85 (0.74-0.99) | 0.002 | 0.87 (0.77-0.99) | 0.002 | 0.89 (0.80-0.98) | <0.001 |
Esophageal | 3 | 1412/1196 | 0.56 (0.40-0.78) | 0.901 | 0.93 (0.74-1.17) | 0.206 | 0.58 (0.42-0.79) | 0.812 | 0.83 (0.71-0.97) | 0.385 | 0.81 (0.72-0.92) | 0.712 |
RCC | 3 | 903/915 | 0.39 (0.26-0.59) | 0.852 | 0.78 (0.64-0.95) | 0.998 | 0.46 (0.32-0.66) | 0.732 | 0.71 (0.58-0.86) | 0.949 | 0.70 (0.61-0.82) | 0.966 |
Lung | 2 | 1585/1544 | 0.66 (0.51-0.87) | 0.473 | 0.75 (0.64-0.88) | 0.385 | 0.75 (0.59-0.95) | 0.458 | 0.73 (0.63-0.85) | 0.453 | 0.78 (0.69-0.87) | 0.273 |
Cervical | 2 | 420/824 | 0.58 (0.36-0.93) | 0.456 | 0.86 (0.59-1.25) | 0.230 | 0.59 (0.39-0.88) | 0.728 | 0.76 (0.59-0.98) | 0.355 | 0.76 (0.63-0.92) | 0.556 |
Prostate | 2 | 650/205 | 1.54 (0.67-3.55) | 0.100 | 0.99 (0.79-1.23) | 0.411 | 1.50 (0.74-3.07) | 0.135 | 1.05 (0.85-1.29) | 0.321 | 1.11 (0.93-1.33) | 0.255 |
Bladder | 2 | 577/618 | 0.44 (0.25-0.77) | 0.799 | 0.79 (0.62-1.01) | 0.334 | 0.48 (0.27-0.84) | 0.907 | 0.74 (0.59-0.93) | 0.317 | 0.74 (0.61-0.90) | 0.338 |
Lymphoma | 2 | 139/240 | 1.19 (0.44-3.23) | 0.729 | 0.82 (0.52-1.31) | 0.635 | 1.26 (0.47-3.39) | 0.789 | 0.86 (0.56-1.34) | 0.559 | 0.93 (0.64-1.35) | 0.535 |
Gastric | 2 | 196/675 | 0.35 (0.19-0.63) | 0.939 | 0.74 (0.44-1.23) | 0.145 | 0.45 (0.26-0.78) | 0.538 | 0.64 (0.40-1.01) | 0.171 | 0.66 (0.51-0.84) | 0.487 |
ALL | 2 | 491/644 | 1.85 (1.20-2.87) | 0.655 | 1.83 (0.69-4.85) | 0.004 | 1.32 (0.81-2.14) | 0.228 | 1.79 (0.81-3.97) | 0.014 | 1.33 (1.10-1.61) | 0.443 |
Others | 9 | 4120/4847 | 0.57 (0.43-0.75) | 0.009 | 0.72 (0.65-0.79) | 0.976 | 0.65 (0.49-0.88) | 0.001 | 0.70 (0.64-0.77) | 0.855 | 0.75 (0.68-0.84) | 0.013 |
Ethnicity | ||||||||||||
Asian | 27 | 10569/11219 | 0.58 (0.48-0.70) | <0.001 | 0.80 (0.75-0.85) | 0.231 | 0.62 (0.52-0.74) | 0.002 | 0.77 (0.72-0.83) | 0.016 | 0.79 (0.73-0.84) | <0.001 |
Caucasian | 20 | 22689/24796 | 0.90 (0.83-0.98) | 0.006 | 0.92 (0.88-0.97) | 0.225 | 0.95 (0.89-1.02) | 0.007 | 0.92 (0.87-0.97) | 0.079 | 0.95 (0.91-0.99) | 0.008 |
African | 1 | 106/257 | 0.70 (0.35-1.43) | / | 1.17 (0.62-2.19) | / | 0.63 (0.37-1.05) | / | 0.98 (0.54-1.80) | / | 0.82 (0.60-1.13) | / |
Mixed | 1 | 130/125 | 2.13 (1.01-4.46) | / | 3.12 (1.70-5.73) | / | 1.00 (0.54-1.85) | / | 2.80 (1.57-5.00) | / | 1.50 (1.05-2.12) | / |
Source of control | ||||||||||||
PB | 24 | 25259/26848 | 0.83 (0.75-0.92) | <0.001 | 0.89 (0.84-0.94) | 0.008 | 0.89 (0.82-0.96) | <0.001 | 0.87 (0.81-0.93) | <0.001 | 0.89 (0.85-0.95) | <0.001 |
HB | 22 | 7966/9184 | 0.61 (0.49-0.75) | <0.001 | 0.83 (0.77-0.89) | 0.213 | 0.67 (0.55-0.82) | <0.001 | 0.79 (0.73-0.87) | 0.024 | 0.81 (0.75-0.88) | <0.001 |
NM | 3 | 269/365 | 1.73 (0.95-3.14) | 0.619 | 1.30 (0.53-3.20) | 0.003 | 1.07 (0.63-1.80) | 0.896 | 1.29 (0.58-2.88) | 0.005 | 1.14 (0.79-1.64) | 0.156 |
Quality score | ||||||||||||
>9 | 24 | 16745/16831 | 0.67 (0.58-0.77) | <0.001 | 0.81 (0.76-0.87) | 0.008 | 0.75 (0.66-0.85) | <0.001 | 0.78 (0.73-0.84) | <0.001 | 0.81 (0.76-0.87) | <0.001 |
≤9 | 25 | 16749/19566 | 0.87 (0.77-0.99) | <0.001 | 0.95 (0.90-1.01) | 0.289 | 0.90 (0.81-1.00) | <0.001 | 0.94 (0.88-1.00) | 0.048 | 0.94 (0.90-0.99) | <0.001 |
Values were in bold, if the 95% CI excluded 1 or P<0.05.
Het: heterogeneity; RCC: renal cell carcinoma; ALL: acute lymphocytic leukemia; HB: hospital based; PB: population based; NM: not mentioned.