Figure 3. Relationships between DNA methylation level of promoter and gene expression during human PED.

(A) The scatter plot of DNA methylation levels of promoter regions and the relative expression levels of corresponding protein-coding genes. The log₂ of the gene expression levels (FPKM) were calculated and are presented. The Pearson correlation coefficients (r) between DNA methylation levels of promoter regions and the scaled expression levels of the corresponding genes across every developmental stage were calculated and are included in the top right corner of each panel. The red and blue fitting curves in each display represent gene expression levels and DNA methylation levels in promoter regions, respectively. The horizontal axis from left to right below each box represents the expression levels from high to low of protein-coding genes, respectively. (B) The same in (A) of lncRNA genes.