Figure 6. Tumor weights after 3 weeks of treatment with idasanutlin, venetoclax or both.

Nude mice carrying orthotopic xenografts of human SH-SY5Y/luc cells were treated by oral gavage with vehicle control, 75 mg/kg idasanutlin, 75 mg/kg venetoclax or both drugs, once daily, six times a week, for three weeks. Tumor weights were compared using the Mann–Whitney test. *p < 0.05, **p < 0.01, ***p < 0.001, n.s: not significant.