Figure 2. Expression of lymphocyte marker genes correspond with experimentally defined measures of immune infiltration.

(A) GO Biological Process enrichment for each of the lymphocyte marker gene sets. Shown here are some of the relevant significant terms (a full list can be found in Supplementary Table 3). Each marker is significantly enriched for immune related terms that are representative of the role of their corresponding cell type. (B) Four categories of immune infiltration (absent, mild, moderate, severe) were defined by H&E staining for the METABRIC cohort [38]. The box plots show that B cell, CTL, Th1, and Th2 marker co-expression correspond with increasing levels of infiltration. All labels were significantly different between the infiltration categories calculated using ANOVA (***p < 1.0e⁻⁵) (C) Average enrichment of marker genes across purified immune cell types from Chtanova et al [34], GSE3982, and GSE1133.