Figure 4. Patients with ER- tumors and high levels of Th1 and CTL infiltration are more likely to have a positive outcome.

For each lymphocyte marker, patients are partitioned into high and low levels using quartiles. Patients with lymphocyte scores in the upper quartile are marked as high (red) and the remaining quartiles are grouped together and labeled low (green). Increased lymphocyte infiltration is associated with better long term survival in ER- tumors (A), and has little effect in ER+ tumors (B). The most extreme difference is seen in patients with high Th1 and CTL infiltration vs. low. Reported p-values were calculated using the log rank test.