Table 3. Meta-analysis of the association between A1298C polymorphism and brain tumor susceptibility in adults.

Comparison	Subgroup	Studies	Heterogeneity test		Association test		Model	Publication bias
			P Value	I2 (%)	OR (95%CI)	P Value		Begg	Egger
C vs. A	Overall	14	0.971	0	1.08(1.00-1.17)	0.056	F	0.743	0.854
	Meningioma	8	0.879	0	1.04(0.93-1.15)	0.522	F
	Glioma	6	0.977	0	1.13(1.01-1.27)	0.033	F
	Caucasian	11	0.978	0	1.10(1.00-1.22)	0.059	F
	Asian	3	0.447	0	1.05(0.93-1.18)	0.474	F
	PB	13	0.958	0	1.07(0.99-1.17)	0.097	F
	HB	1	NA	NA	1.13(0.90-1.43)	0.296	F
AC vs. AA	Overall	14	0.717	0	1.22(1.09-1.36)	<0.001	F	0.584	0.189
	Meningioma	8	0.649	0	1.12(0.97-1.30)	0.119	F
	Glioma	6	0.868	0	1.35(1.15-1.60)	<0.001	F
	Caucasian	11	0.981	0	1.31(1.14-1.51)	<0.001	R
	Asian	3	0.13	51	1.11(0.86-1.44)	0.413	R
	PB	13	0.764	0	1.19(1.06-1.34)	0.002	F
	HB	1	NA	NA	1.50(1.05-2.14)	0.025	F
CC vs. AA	Overall	14	0.941	0	1.03(0.86-1.22)	0.771	F	0.274	0.131
	Meningioma	8	0.636	0	0.98(0.77-1.24)	0.854	F
	Glioma	6	0.987	0	1.09(0.84-1.40)	0.531	F
	Caucasian	11	0.916	0	0.99(0.79-1.25)	0.942	F
	Asian	3	0.51	0	1.07(0.82-1.40)	0.599	F
	PB	13	0.914	0	1.01(0.84-1.22)	0.883	F
	HB	1	NA	NA	1.11(0.69-1.77)	0.676	F
CC+AC vs. AA	Overall	14	0.88	0	1.18(1.06-1.30)	0.002	F	0.743	0.328
	Meningioma	8	0.836	0	1.09(0.95-1.25)	0.208	F
	Glioma	6	0.921	0	1.29(1.11-1.51)	0.001	F
	Caucasian	11	0.991	0	1.25(1.09-1.42)	0.001	F
	Asian	3	0.212	35.5	1.08(0.92-1.27)	0.35	F
	PB	13	0.893	0	1.16(1.04-1.29)	0.009	F
	HB	1	NA	NA	1.38(0.99-1.93)	0.058	F
CC vs. AA+AC	Overall	14	0.841	0	0.93(0.78-1.09)	0.363	F	0.511	0.085
	Meningioma	8	0.394	4.6	0.92(0.73-1.16)	0.483	F
	Glioma	6	0.983	0	0.93(0.73-1.19)	0.561	F
	Caucasian	11	0.844	0	0.87(0.70-1.09)	0.222	F
	Asian	3	0.416	0	1.00(0.78-1.29)	0.990	F
	PB	13	0.786	0	0.93(0.78-1.12)	0.448	F
	HB	1	NA	NA	0.89(0.58-1.36)	0.587	F

OR, odds ratio; CI, confidence interval; F, fixed-effects model; R, random-effects model; NA, not available; PB, population-based; HB, hospital-based