Table 2. Characteristics of patients in dyskinesia trials.
| Trial | Patients (Drug/Placebo) | Age years | Duration of PD | H&Y | UPDRS IV | Dyskinesia | UPDRS III | |||
|---|---|---|---|---|---|---|---|---|---|---|
| Drug | Placebo | Drug | Placebo | Drug | Placebo | |||||
| Verhagen Metman 1998 | 18 (14/14) (4 dropout) | 60 ± 2 | 13 ± 1.3 | 3.5 ± 0.2 | 1(Items32, 34, 39) | 4(Items32, 34, 39) | 3.6 ± 2.25 (AIMs) | 7.0 ± 3.38 (AIMs) | NA | NA |
| Luginger 2000 | 11 (10/10) (1 dropout) | 63.5 ± 8.2 | 10.1 ± 5.1 | 2.8 ±1.2 | 7.0 ± 8.2 (IVa) | 14.5 ± 9.4 (IVa) | 9.1 ± 9.1 (DRS) | 19.3 ± 13.7 (DRS) | 50 ± 20 | 68 ± 20 |
| Snow 2000 | 24 (22/22) (2 dropout) | 64.2 ± 8.9 | 10.6 ± 3.6 | NA | 3.2 ± 1.6 (IVa) | 4.3 ± 1.5 (IVa) | 22.0 ± 13.2 (DRS) | 29.0 ± 12.6 (DRS) | 22.3 ±12.1 | 23.4 ±9.0 |
| Del Dotto 2001 | 9 (5/4) (0 dropout) | 59.7 ± 8 | 8.4 ± 3.0 | 3.0 ±0.5 | NA | NA | 4.1 ± 1.7 (AIMs) | 8.3 ± 1.8 (AIMs) | 21.6 ± 9.5 | 23.5 ± 9.7 |
| Thomas 2004 | 40 (17/18) (5 dropout) | 62.7 ± 5.2 | 7.9 ±2.2 | 2.6 ±0.2 | 2.0 ± 1.1 (IVa) | 6.1 ± 2.6 (IVa) | 10.5 ± 1.3 (DRS) | 20.2 ±1.6 (DRS) | 48.1 ± 7.8 | 52.5 ± 8.3 |
| Silva-Junior 2005 | 20 (9/9) (2 dropout) | 60.6 ± 9.8 | 8.9±3.8 | 2.5±0.5 | 2.8±2.1 (IVa) | 3.7±1.8 (IVa) | 6.8±4.9 (CDRS) | 13.0±11.5 (DRS) | 16.3±9.3 | 18.7±5.3 |
| Wolf 2010 | 32 (14/17) (1 dropout) | 67±7.7 | 16.8±5.9 | NA | 3.6±0.4 (Items32, 33) | 4.4±0.4 (Items32, 33) | NA | NA | 25.8±3.4 | 27.7±3.7 |
| Sawada 2010 | 35 (30/32) (5 dropout) | 63.9±7.6 | 13.5±4.5 | NA | 5.87±3.6 (IVa) | 7.73±3.1 (IVa) | 1.1±0.7 (RDRS) | 2.1±0.8 (RDRS) | 18.32±14.0 | 18.12±8.6 |
| Goetz 2013 | 68 (36/32) (7 dropout) | 65.4±8.2 | 9.0±3.5 | Median 2 (1-4) | NA | NA | 20.71 ± 8.89 (UDysRS) | 34.07 ± 12.51 (UDysRS) | NA | NA |
| Ory-Magne 2014 | 56 (27/29) (0 dropout) | 64.0±7.7 | 13.6±6.7 | NA | 3.3±1.7 (Items32, 33) | 4.9±1.5 (Items32, 33) | 2.4 ± 2.8 (AIMs) | 5.7 ± 2.5 (AIMs) | 16.0±8.1 | 17.0±8.2 |
| Pahwa 2016 | 43 (21/22 ) (5 dropout) | 66.0±9.5 | 9.5±5.0 | 2.5±0.7 | 9.3±2.8 ( IV) | 11.7±3.1 (IV) | 25.9 ± 12.1 (UDysRS) | 32.5 ± 17.8 (UDysRS) | NA | NA |
AIMS: Abnormal Involuntary Movements Scale; CDRS: Clinical Dyskinesia Rating Scale; DRS: Dyskinesia Rating Scale; UPDRS, Unified Parkinson's Disease Rating Scales; H&Y: Hoehn and Yahr Parkinson's disease staging scale; UDysRS, Unified Dyskinesia Rating Scale; RDRS, Rush Dyskinesia Rating Scale.