Table 3. Pooled hazard ratios for OS according to subgroup analyses.
| OS-Intratumor subgroup | Study number | Case number | HR (95%CI)-model | P value | Heterogenety | |
|---|---|---|---|---|---|---|
| I2 (%) | P | |||||
| CD8+ | ||||||
| Ethnicity | ||||||
| Asian | 9 | 1348 | 0.72 (0.60-0.87) - fixed | 0.001 | 0 | 0.619 |
| Caucasion | 3 | 175 | 0.77 (0.46-1.29) - fixed | 0.318 | 25.9 | 0.259 |
| Sample size | ||||||
| ≥ 100 | 7 | 1183 | 0.74 (0.48-1.12) - fixed | 0.001 | 0 | 0.445 |
| < 100 | 5 | 340 | 0.73 (0.60-0.88) - fixed | 0.155 | 0 | 0.528 |
| Cut-off value | ||||||
| Median | 8 | 1133 | 0.73 (0.60-0.89) - fixed | 0.002 | 0 | 0.504 |
| Others | 4 | 390 | 0.74 (0.50-1.08) - fixed | 0.114 | 0 | 0.444 |
| FOXP3+ | ||||||
| Ethnicity | ||||||
| Asian | 11 | 1265 | 1.66 (1.08-2.56) - random | 0.022 | 73.0 | <0.001 |
| Caucasion | 2 | 104 | 0.70 (0.33-1.48) – fixed | 0.350 | 0 | 0.709 |
| Sample size | ||||||
| ≥ 100 | 7 | 970 | 1.60 (1.09-2.36) - random | 0.016 | 80.8 | <0.001 |
| < 100 | 6 | 399 | 1.23 (0.47-3.19) - random | 0.617 | 58.5 | 0.025 |
| Cut-off value | ||||||
| median | 9 | 991 | 1.66 (0.96-2.88) -random | 0.072 | 78.0 | <0.001 |
| others | 4 | 378 | 1.37 (0.93-2.03) – fixed | 0.115 | 33.0 | 0.214 |
OS: overall survival; HR: hazard ratio; CI: confidence interval.