Table 2. Comparison of incidence and hazard ratio of AAD between patients with and without ADPKD, stratified by gender, age and medical diseases.
| ADPKD group (N = 2076) | Non-ADPKD group (N = 20760) | |||||||
|---|---|---|---|---|---|---|---|---|
| Subgroup | AAD | PY | Rate | AAD | PY | Rate | IRR (95% CI) | Adjusted HR (95% CI) |
| Total | 19 | 13312 | 142.7 | 22 | 140417 | 15.7 | 9.11 (4.93 - 16.83)‡ | 5.49 (2.86 - 10.52)‡ |
| Gender | ||||||||
| Female | 5 | 7041 | 71 | 7 | 73581 | 9.5 | 7.46 (2.37 - 23.52)‡ | 5.22 (1.53 - 17.86)† |
| Male | 14 | 6271 | 223.2 | 15 | 66836 | 22.4 | 9.95 (4.8 - 20.61)‡ | 5.41 (2.51 - 11.64)‡ |
| Age | ||||||||
| 18-39 | 1 | 3808 | 26.3 | 0 | 38391 | 0 | ---§ | ---§ |
| 40-65 | 14 | 8346 | 167.7 | 11 | 87400 | 12.6 | 13.33 (6.05 - 29.36)‡ | 6.82 (2.96 - 15.69)‡ |
| >65 | 4 | 1158 | 345.4 | 11 | 14626 | 75.2 | 4.59 (1.46 - 14.42)‡ | 3.5 (1.09 - 11.26)* |
| Medical diseases | ||||||||
| Hypertension | ||||||||
| No | 2 | 2157 | 92.7 | 2 | 93326 | 2.1 | 43.27 (6.09 - 307.14)‡ | 46.69 (6.07 - 359.4)‡ |
| Yes | 17 | 11155 | 152.4 | 20 | 47091 | 42.5 | 3.59 (1.88 - 6.85)‡ | 4.46 (2.29 - 8.7)‡ |
| Diabetes mellitus | ||||||||
| No | 17 | 11366 | 149.6 | 20 | 118088 | 16.9 | 8.83 (4.63 - 16.86)‡ | 5.28 (2.66 - 10.48)‡ |
| Yes | 2 | 1946 | 102.8 | 2 | 22329 | 9 | 11.47 (1.62 - 81.46)* | 12.31 (1.55 - 98.09)* |
| Dyslipidemia | ||||||||
| No | 12 | 8668 | 138.4 | 17 | 107454 | 15.8 | 8.75 (4.18 - 18.32)‡ | 4.25 (1.92 - 9.39)‡ |
| Yes | 7 | 4644 | 150.7 | 5 | 32963 | 15.2 | 9.94 (3.15 - 31.31)‡ | 8.7 (2.69 - 28.2)‡ |
| Gout | ||||||||
| No | 13 | 9412 | 138.1 | 16 | 122461 | 13.1 | 10.57 (5.09 - 21.98)‡ | 8.1 (3.64 - 18.03)‡ |
| Yes | 6 | 3900 | 153.8 | 6 | 17956 | 33.4 | 4.6 (1.48 - 14.27)‡ | 2.99 (0.96 - 9.38) |
| Atrial fibrillation | ||||||||
| No | 19 | 12952 | 146.7 | 21 | 138230 | 15.2 | 9.66 (5.19 - 17.96)‡ | 5.86 (3.04 - 11.33)‡ |
| Yes | 0 | 360 | 0 | 1 | 2187 | 45.7 | ---§ | ---§ |
| Ischemic heart disease | ||||||||
| No | 12 | 9587 | 125.2 | 12 | 116888 | 10.3 | 12.19 (5.48 - 27.14)‡ | 7.61 (3.13 - 18.49)‡ |
| Yes | 7 | 3725 | 187.9 | 10 | 23529 | 42.5 | 4.42 (1.68 - 11.62)† | 3.5 (1.3 - 9.43)* |
| Heart failure | ||||||||
| No | 15 | 11828 | 126.8 | 16 | 134469 | 11.9 | 10.66 (5.27 - 21.56)‡ | 6.3 (2.99 - 13.3)‡ |
| Yes | 4 | 1484 | 269.5 | 6 | 5948 | 100.9 | 2.67 (0.75 - 9.47) | 2.54 (0.65 - 9.93) |
| Cerebrovascular accident | ||||||||
| No | 14 | 11247 | 124.5 | 17 | 129509 | 13.1 | 9.48 (4.67 - 19.24)‡ | 5.52 (2.6 - 11.73)‡ |
| Yes | 5 | 2065 | 242.1 | 5 | 10908 | 45.8 | 5.28 (1.53 - 18.25)† | 5.74 (1.48 - 22.36)* |
| Hemorrhagic stroke | ||||||||
| No | 17 | 12580 | 135.1 | 20 | 138646 | 14.4 | 9.37 (4.91 - 17.88)‡ | 5.67 (2.85 - 11.27)‡ |
| Yes | 2 | 732 | 273.2 | 2 | 1771 | 112.9 | 2.42 (0.34 - 17.18) | 20.42 (0.63 - 664.32) |
| Peripheral vascular disease | ||||||||
| No | 18 | 12310 | 146.2 | 20 | 135673 | 14.7 | 9.92 (5.25 - 18.75)‡ | 5.94 (3.02 - 11.68)‡ |
| Yes | 1 | 1002 | 99.8 | 2 | 4744 | 42.2 | 2.37 (0.21 - 26.11) | 3.38 (0.21 - 54.62) |
| Chronic kidney disease | ||||||||
| No | 5 | 6207 | 80.6 | 19 | 137040 | 13.9 | 5.81 (2.17 - 15.56)‡ | 5.62 (2 - 15.78)† |
| Yes | 14 | 7105 | 197 | 3 | 3377 | 88.8 | 2.22 (0.64 - 7.72) | 1.71 (0.47 - 6.19) |
| Malignancy of kidney or bladder | ||||||||
| No | 18 | 12862 | 139.9 | 22 | 139769 | 15.7 | 8.89 (4.77 - 16.58)‡ | 5.38 (2.78 - 10.44)‡ |
| Yes | 1 | 450 | 222.2 | 0 | 648 | 0 | ---§ | ---§ |
*p < 0.05, †p < 0.01, ‡p < 0.001
§Insufficient case number for statistical analysis
Rate denotes incidence rate (per 100,000 person-years).
Adjusted HR (hazard ratio) indicates multivariate analysis with adjusting for age, gender, and comorbidities.
Abbreviations: AAD, aortic aneurysm/dissection; ADPKD, autosomal dominant polycystic kidney disease; PY, person-year; IRR, incidence rate ratio; CI, confidence interval.