Table 4. Cox regression analysis for the risk of ADPKD-associated AAD with interaction of hypertension.
| Univariate | Multivariate* | |||||
|---|---|---|---|---|---|---|
| AAD | HR | 95% CI | p-value | HR | 95% CI | p-value |
| Neither ADPKD nor hypertension | 1.00 | 1.00 | ||||
| ADPKD only | 43.85 | 6.17 - 311.48 | 0.0002 | 30.98 | 5.39 - 311.40 | 0.0003 |
| Hypertension only | 19.53 | 4.56 - 83.57 | <.0001 | 13.05 | 2.92 - 58.30 | 0.0008 |
| ADPKD and hypertension | 71.02 | 16.41 - 307.40 | <.0001 | 39.85 | 7.64 - 207.73 | <.0001 |
Abbreviations: ADPKD, autosomal dominant polycystic kidney disease; AAD, aortic aneurysm/dissection; HR, hazard ratio; CI, confidence interval.
*Multivariate analysis was done with adjusting for age, gender, and comorbidities.