Table 2. Distinctive mechanisms of different forms of VK that triggers programmed cell death by apoptosis.
Different forms of Vitamin K | Cancer/Cancer Cell | Target molecule |
---|---|---|
VK | Pancreatic cancer | Caspase dependent apoptosis via the MAP kinase pathway [127] |
VK2 | Leukemia Leukemia and hepatocellular carcinoma | G0/G1 arrest along with Apoptosis [116] BaK mediated apoptosis [118] Regulating MMP [120] JNK cascade and FasL [126] |
VK3 | Leukemia | Fas/FasL [102] |
VK3 + Vitamin C | Leukemia | ROS, NF-kB [113] |
VK3 + Vitamin D-Fraction | Renal cell carcinoma | G0/G1 arrest along with Apoptosis [75] |