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. 2017 May 19;8(34):57782–57799. doi: 10.18632/oncotarget.17997

Table 2. Distinctive mechanisms of different forms of VK that triggers programmed cell death by apoptosis.

Different forms of Vitamin K Cancer/Cancer Cell Target molecule
VK Pancreatic cancer Caspase dependent apoptosis via the MAP kinase pathway [127]
VK2 Leukemia Leukemia and hepatocellular carcinoma G0/G1 arrest along with Apoptosis [116] BaK mediated apoptosis [118] Regulating MMP [120] JNK cascade and FasL [126]
VK3 Leukemia Fas/FasL [102]
VK3 + Vitamin C Leukemia ROS, NF-kB [113]
VK3 + Vitamin D-Fraction Renal cell carcinoma G0/G1 arrest along with Apoptosis [75]