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. 2017 May 11;8(34):57907–57933. doi: 10.18632/oncotarget.17826

Figure 9. A schematic model for the interplay between AR and C1orf64.

Figure 9

This model shows a negative interplay between AR and C1orf64. In this process, AR activation represses C1orf64 transcription and C1orf64, in turn, acts as a corepressor of AR and negatively regulates the AR-mediated induction of PIP expression and AR reporter activity. Chaperone protein 14-3-3 interacts with C1orf64 and has a regulatory function in this model. The other aspect of this interplay involves a cross-talk between the AR and ER signaling in which, AR activation has a repressive effect on the ER-mediated induction of PGR. In addition, C1orf64 is necessary for PGR expression and its repression by AR has an inhibitory effect on the positive regulation of ER activity by C1orf64. Red arrows denote a stimulatory effect and black lines indicate a repressive function.