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. 2017 Apr 7;6(8):e1304337. doi: 10.1080/2162402X.2017.1304337

Table 1.

Expression of programmed death ligand 1 (PD-L1) in Kaposi's sarcoma (KS).

Patient Age Years on cART Years HIV positive Years since first KS diagnosed Peripheral blood CD4+ count (cells/mm3) Peripheral blood CD8+ count (cells/mm3) KS case or normal skin control Amount of tumor PD-L1 tumor-cell expression PD-L1-expressing macrophages Tissue CD8+ count (cells/mm2) KS Staging (ACTG criteria) KS grade Plasma HHV8 viral load copies/mL
S926 53 2.8 26.3 1.3 499 830 Case Small 0 Absent 76 T1I0S0 Patch 42400
              Control Absent 0 Absent 24      
M907 59 16.2 16.3 13.7 111 1101 Case Small 0 Rare 106 T1I0S0 Plaque 0
              Control Absent 0 Absent 32      
M515 54 10.5 13.2 13.2 913 482 Case Abundant 1+ Numerous 292 T1I0S0 Nodular 0
              Control Absent 0 Absent 15      
M610 49 9.0 9.9 3.0 574 820 Case Moderate 1+ Rare 44 T1I0S0 Nodular 0
              Control Absent 0 Absent 5      
L292 37 1.2 1.2 1.2 298 1497 Case Abundant 1+ Moderate 225 T1I1S1 Nodular 0
              Control* Focal 1+ (focal) Rare 111      
S371 58 8.3 8.3 8.3 677 961 Case Focal 0 Absent 36 T1I0S1 Lymphangiectatic 0
              Control Absent 0 Absent 15      
L432 45 0.8 4.4 0.8 459 709 Case Small 1+ (focal) Rare 190 T0I0S0 Plaque 1650
              Control Absent 0 Absent 13      
R366 39 11.0 12.0 11.1 1200 961 Case Small 0 Absent 72 T0I0S0 Patch 0
              Control Absent 0 Absent 7      
G099 43 10.5 13.4 0.1 1219 732 Case Abundant 1 Rare 156 T0I0S0 Plaque 0
              Control Absent 0 Absent 34      
G963 33 1.0 2.0 0.9 661 738 Case Absent 0 Absent 22 T0I0S0 Patch 541
              Control Absent 0 Absent 23      

This table summarizes the results of histological examination of Kaposi's sarcoma (KS) biopsies (cases) and normal skin controls from 10 patients with KS despite established, successful antiretroviral therapy, undetectable plasma HIV-1 RNA load and good CD4+ T-cell counts. The amount of KS tumor in each was semi-quantitatively assessed. Expression of programmed death ligand 1 (PD-L1) by tumor-cells was judged according to a scoring system from 0 to 3+. No tumors showed expression greater than 1+ (any staining above background). The number of tumor-infiltrating PD-L1-expressing macrophages was semi-quantitatively assessed. The number of tumor-infiltrating CD8+ T cells was calculated as cells per mm2.

*

indicates this control biopsy contained a focal area of tumor not clinically apparent.