Table 3.
CD4+ and CD8+ TEM and TN cells in patients relative to donors.
| Donor HCMV+ PBMCs | Donor HCMV− PBMCs | Patient HCMV+PBMCs | Patient HCMV−PBMCs | Patient HCMV+biopsy | Patient HCMV−biopsy | ||
|---|---|---|---|---|---|---|---|
| (n= 9) | (n = 7) | (n = 17) | (n = 2) | (n = 13) | (n = 2) | Statistical analysis | |
| % of CD4+EM | 30.1 ± 5.1 | 18.7 ± 1.2 | 42.3 ± 5.1 | 25.2 | 62.1 ± 4.1 | 70.7 | Two-way ANOVA, Bonferroni's multiple comparison test: |
| P < 0.01 for Donor HCMV+ vs. patient HCMV− biopsy, | |||||||
| P < 0.0001 for Donor HCMV+ vs. patient HCMV+ biopsy, | |||||||
| P < 0.0001 for Donor HCMV− vs. patient HCMV− biopsy, | |||||||
| P < 0.0001 for Donor HCMV− vs. patient HCMV+ biopsy, | |||||||
| P < 0.01 for Donor HCMV− vs. patient HCMV+ PBMC, | |||||||
| P < 0.05 patients' HCMV− PBMC vs. patient HCMV− biopsy | |||||||
| P < 0.01 patients' HCMV+ PBMC vs. patient HCMV+ biopsy and | |||||||
| P < 0.01 patients' HCMV− PBMC vs. patient HCMV+ biopsy | |||||||
| % of CD4+N | 36.6 ± 5.1 | 44.9 ± 2.1 | 19.4 ± 3.8 | 27.7 | 5.2 ± 1.9 | 4.1 | Two-way ANOVA, Bonferroni's multiple comparison test: |
| P < 0.05 for Donor HCMV+ vs. patient HCMV− biopsy, | |||||||
| P < 0.001 for Donor HCMV+ vs. patient HCMV+ biopsy, | |||||||
| P < 0.05 for Donor HCMV+ vs. patient HCMV− biopsy, | |||||||
| P < 0.01 for Donor HCMV− vs. patient HCMV− biopsy, | |||||||
| P < 0.0001 for Donor HCMV− vs. patient HCMV+ biopsy and | |||||||
| P < 0.001 for Donor HCMV− vs. patient HCMV+ PBMC | |||||||
| % of CD8+EM | 25.9 ± 4.2 | 16.6 ± 3.5 | 28.1 ± 4.1 | 22.1 | 52.1 ± 5.6 | 54.0 | Two-way ANOVA, Bonferroni's multiple comparison test: |
| P < 0.001 for Donor HCMV+ PBMC vs. patient HCMV+ biopsy, P < 0.05 for Donor HCMV−PBMC vs. patient HCMV− biopsy, | |||||||
| P < 0.0001 for Donor HCMV−PBMC vs. patient HCMV+ biopsy and | |||||||
| P < 0.0001 for patients' HCMV+ biopsy vs. patient HCMV+ PBMC | |||||||
| % of CD8+N | 26.9 ± 5.7 | 40.60 ± 5.5 | 26.9 ± 4.4 | 21.1 | 10.9 ± 2.8 | 0.8 | Two-way ANOVA, Bonferroni's multiple comparison test : |
| P < 0.01 for Donor HCMV−PBMC vs. patient HCMV− biopsy and P < 0.001 for Donor HCMV−PBMC vs. patients HCMV+ biopsy |