Table 3.

Correlation of histologic tumor necrosis with clinicopathological characteristics of intrahepatic cholangiocarcinoma.

Clinicopathological analysis
Variable	Necrosis positive	Necrosis negative	p
No. of patients	57	31
Patient age, years			0.325
≤ 60	23 (40.4%)	14 (45.2%)
>60	34 (59.6%)	17 (54.8%)
Gender			0.662
Male	17 (40.5%)	14 (41.2%)
Female	25 (59.5%)	20 (58.8%)
Tumor nodules			0.288
Solitary	25 (43.9%)	10 (32.3%)
Multiple	32 (56.1%)	21 (67.7%)
Tumor diameter			0.586
Small	17 (29.8%)	11 (35.5%)
Large	40 (70.2%)	20 (64.5%)
Bilobular hepatic tumor involvement			0.180
Yes	36 (63.2%)	15 (48.4%)
No	21 (36.8%)	16 (51.6%)
Distant metastases			0.658
With	1 (1.8%)	1 (3.2%)
Without	56 (98.2%)	30 (96.8%)
Angioinvasion			0.031
With	1 (1.8%)	4 (12.9%)
Without	56 (98.2%)	27 (87.1%)
Lymphangiosis carcinomatosa			0.093
Positive	29 (50.9%)	10 (32.3%)
Negative	28 (49.1%)	21 (67.7%)
Perineural sheath infiltration			0.371
Positive	18 (31.6%)	7 (22.6%)
Negative	39 (68.4%)	24 (77.4%)
Histological differentiation			0.308
Well/moderate	37 (67.0%)	23 (76.7%)
Poor	20 (34.0%)	8 (23.3%)
Pathological T stage			0.103
T1/T2	19 (33.3%)	16 (51.7%)
T3/T4	38 (66.7%)	15 (48.3%)
Pathological N stage			0.0.85
Positive	26 (45.6%)	9 (26.7%)
Negative	31 (54.4%)	22 (73.3%)
Tumor recurrence			0.368
With	42 (73.7%)	20 (64.5%)
Without	15 (26.3%)	11 (35.5%)
Local recurrence		0.195
With	14 (24.6%)	4 (12.9%)
Without	43 (75.4%)	27 (87.1%)
CD68-positive TAMs in TCA			0.109
High	29 (50.9%)	21 (69.0%)
Low	28 (49.1%)	10 (31.0%)
CD68-positive TAMs in TIF			0.251
High	25 (50.0%)	10 (36.0%)
Low	25 (50.0%)	16 (64.0%)
Variable	Mild necrosis	Severe necrosis	p
No. of patients	34	23
Multiple tumor nodules			0.048
With	9 (26.5%)	12 (52.2%)
Without	25 (73.5%)	11 (47.8%)