Table 4.

Multivariate analysis of prognostic factors in patients with intrahepatic cholangiocarcinoma.

Multivariate analysis (Overall Survival)
Variable	Category	Odds ratio	p	Confidence interval
Histologic differentiation	well or moderate/ poor	2.266	0.040	1.038–4.946
T status	T1,T2/T3,T4	1.688	0.236	0.710–4.009
Overall tumor recurrence	negative/positive	0.011	0.0001	0.001–0.093
Local tumor recurrence	negative/positive	0.707	0.401	0.315–1.588
CD68-positive TAMs in the tumor invasive front	high/low	2.752	0.016	1.207–6.275
Tumor necrosis	negative/positive	0.244	0.002	0.100–0.596
Multivariate analysis (Recurrence-free survival)
Variable	Category	Odds ratio	p	Confidence interval
Tumor nodules	solitary/multiple	0.301	0.001	0.149–0.606
Perineural sheet infiltration	negative/positive	0.370	0.008	0.178–0.772
Histologic differentiation	well or moderate/ poor	2.123	0.047	1.010–4.460
Lymph node Involvement	negative/positive	0.542	0.066	0.282–1.042
CD68-positive TAMs in the tumor invasive front	high/low	0.558	0.094	0.282–1.104