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. Author manuscript; available in PMC: 2018 Oct 10.
Published in final edited form as: J Control Release. 2017 Mar 11;263:120–131. doi: 10.1016/j.jconrel.2017.03.017

Figure 1. Physiochemical properties and diffusion behaviors of CDDP -loaded nanoparticles.

Figure 1

(A) Transmission electron micrograph of CDDP -BPN (upper panel) and CDDP-UPN (lower panel). Scale bars = 100 nm. (B) Stability of CDDP -BPN and CDDP-UPN in ACSF and media with 10% FBS over time. (C) In vitro drug release kinetics of CDDP-BPN in PBS (pH 7.0) at 37°C (n=3). (D) In vitro cytotoxicity of carrier-free CDDP and CDDP-BPN in F98 rat GBM cells (n=3); *** p < 0.005. (E) Representative trajectories of CDDP-BPN and CDDP-UPN diffusing in rat brain tissue ex vivo. (F) Median MSD of CDDP-BPN and CDDP-UPN at a timescale of t = 1 s in at least n = 3 rat brain tissues (> 100 particles tracked in individual samples). *P< 0.05. (G) In vivo distribution of CDDP-BPN (red) and CDDP-UPN (green) in rat brain striatum following administration via CED. Cell nuclei are stained by DAPI (blue). Scale bar = 1 mm. (H) Volume of in vivo distribution of CDDP-BPN and CDDP-UPN in rat hemispheres (n > 3 rats).