Table 2.

Summary of results from Bayesian statistical analyses of craving measures, cocaine use outcomes, and DTI outcomes.

Outcomes for Clinical variables	Variable
	BSCS	VAS	OCDUS	Cocaine use (TLFB)	Cocaine Use (UDS)
Post prob: Treatment × Time	0.97	>0.99	0.60	0.99	0.75
Post prob: Simple Effect of Time (PIO)	p(b<0) > 0.99	p(b<0) > 0.99	p(b<0) = 0. 64	p(O.R. < 1) > 0.99	p(O.R. < 1) = 0.38
Estimate: Simple effect of Time (PIO)	b = −0.24 (−0.36–−0.12)	b = −3.84 (−5.22–−2.46)	b = −0.07 (−0.45–0.30)	O.R. = 0.74 (0.66–0.85)	O.R. = 1.05 (0.75–1.47)
Post prob: Simple effect of Time (PLC)	p(b<0) = 0.98	p(b<0) > 0. 99	p(b>0) = 0. 77	p(O.R. < 1) = 0.89	p(O.R. < 1) = 0.10
Estimate: Simple effect of Time (PLC)	b = −0.09 (−0.18–−0.01)	b = −1.34 (−2.19–−0.51)	b = 0.15 (−0.25–0.55)	O.R. = 0.94 (0.84–1.04)	O.R. = 1.24 (0.88−1.78)
Outcomes for DTI variables	gCC FA	sCC FA	ATR FA (hemisphere)	PTR FA (hemisphere)	EXTC FA (hemisphere)	CING FA (hemisphere)
Post Prob: Treatment Controlling for Baseline FA	0.99	0.99	0.93 (L) 0.93 (R)	0.98 (L) 0.97 (R)	0.93 (L) 0.52 (R)	0.68 (L) 0.54 (R)
Estimate of Simple of PIO	b = 25.96 (4.84–45.05)	b = 29.12 (6.52–51.92)	b = 12.59 (L) (−4.84–30.16) b = 13.83 (R) (−5.26–32.99)	b = 15.29 (L) (1.19–29.42) b = 15.96 (R) (−1.06–33.10)	b = 8.86 (L) (−3.09–20.87) b = 0.27 (R) (−9.53–10.06)	b = 4.29 (L) (−14.61–23.42) b = 1.26 (R) (−27.60–30.18)

Note. Post Prob = posterior probability; PIO = pioglitazone; PLC = placebo; p = probability; b = beta coefficient (with 95% credible intervals); O.R. = odds ratio. BSCS = Brief Substance Craving Scale; VAS = visual analog scale; OCDUS = Obsessive Compulsive Drug Use Scale; TLFB = Timeline Followback; UDS = urine drug screen; FA = fractional anisotropy value; gCC = genu of corpus callosum; sCC = splenium of corpus callosum; ATR = anterior thalamic radation; PTR = posterior thalamic radiation; EXTC = External Capsule; CING = Cingulate.

^*Coefficients are in the log-form.