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Apparent Ki values for various inhibitors of uridine phosphorylase activity in Schistosoma mansoni and mouse liver.
| Compound | Apparent Ki (μM) ± S.E.E.a | Ratiob | |
|---|---|---|---|
|
| |||
| S. mansoni | Mouse | ||
| 5-Benzylacyclouridine | 5.2 ± 0.20 | 3.12 ± 0.21 | 0.60 |
| 5-(Benzyloxybenzyl)acyclouridine | 4.1 ± 0.25 | 1.25 ± 0.10 | 0.30 |
| 5-(Benzyloxybenzyloxybenzyl)acyclouridine | 3.5 ± 0.23 | 519 ± 34 | 148 |
Standard error of estimation,
Ratio of mouse liver apparent Ki to S. mansoni apparent Ki (data from el Kouni et al, 1988).
