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. 2017 Sep 11;7:11198. doi: 10.1038/s41598-017-10580-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Treatment of CD4+ T cells decrease in KC-Tie2 mice with topical S12 and S14 analogs results in decreased CD4+ infiltration. (A) Representative images of CD4+ stained dorsal skin sections from KC-Tie2 mice following treatment with S12, S14 or vehicle cream. (B) Quantification of CD4+ T cell numbers in KC-Tie2 mice treated with vehicle (n = 8), S12 (n = 9) and S14 (n = 9). Values shown represent the mean # of cells/FOV (field of view) ± SEM. Data were analyzed using a Student’s t-test. P values are as indicated. Scale bar = 50 μm.