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. 2017 Sep 11;7:11198. doi: 10.1038/s41598-017-10580-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Solenopsin analogs S12 and S14 inhibit IL-22 expression. Compounds cause a significant decrease in IL-22 mRNA expression. The compounds also increase levels of IL-12 but no changes in IL-23 production by DC. Mouse DC were pre-incubated for 12 h with 10 µM compounds and then stimulated with LPS. IL-22 mRNA expression was measured by qRT-PCR. (A) Concentrations of IL-12 (B) and IL-23 (C) in the culture supernatants were determined by ELISA. Results are expressed as mean ± SD.