Table 3.
Association of the relative abundance of single gut bacteria with clinical domains in hospitalized patients. Significant correlations between relative abundance of specific taxa of gut microbiota, identified by 16S rRNA microbial profiling analyses, and clinical parameters (number of drugs, Rockwood Clinical Frailty Scale and CIRS Comorbidity Score) at multivariate linear regression models. Taxa identified in the gut microbiota but lacking any significant correlation with the considered clinical parameters are not shown, but are fully listed in Supplemental Material.
| Taxa | Number of drugs | Rockwood Clinical Frailty Scale | CIRS Comorbidity Score | |||
|---|---|---|---|---|---|---|
| Beta ± SE | p* | Beta ± SE | p** | Beta ± SE | p*** | |
| Asteroleplasma | 0.0008 ± 0.00004 | 0.03 | — | — | — | — |
| Bradyrhizobium | 0.000002 ± 0.0000001 | 0.02 | — | — | — | — |
| Coprobacter | 0.0005 ± 0.0002 | 0.04 | — | — | — | — |
| Enterobacter | — | — | — | — | 0.00003 ± 0.00001 | 0.02 |
| Fonticella | — | — | 0.0009 ± 0.0004 | 0.04 | — | — |
| Gordonibacter | 0.00003 ± 0.00001 | 0.04 | — | — | — | — |
| Helicobacter | 0.0005 ± 0.00002 | 0.003 | — | — | — | — |
| Massilia | −0.000007 ± 0.000003 | 0.04 | — | — | — | — |
| Morganella | — | — | — | — | 0.00004 ± 0.00001 | 0.004 |
| Oscillospira | — | — | 0.0005 ± 0.00002 | 0.02 | — | — |
| Parabacteroides | 0.003 ± 0.001 | 0.02 | — | — | — | — |
| Peptococcus | — | — | 0.00001 ± 0.000006 | 0.02 | — | — |
| Porphyromonas | — | — | 0.0001 ± 0.00005 | 0.02 | — | — |
| Prevotella | 0.003 ± 0.0001 | 0.01 | 0.00001 ± 0.000006 | 0.02 | — | — |
| Pantoea | — | — | — | — | 0.0002 ± 0.00008 | 0.008 |
| Roseburia | — | — | — | — | −0.00003 ± 0.00001 | 0.02 |
| Scardovia | — | — | — | — | 0.00002 ± 0.000008 | 0.003 |
| Shuttleworthia | — | — | — | — | −0.002 ± 0.001 | 0.04 |
| U. m. of candidate division TM7 phylum | — | — | — | — | 0.000001 ± 0.000001 | 0.01 |
| U. m. of Bacilli class | −0.00004 ± 0.000001 | 0.02 | — | — | — | — |
| U. m. of Clostridiaceae 1 family | — | — | 0.00003 ± 0.00001 | 0.04 | — | — |
| U. m. of Lachnospiraceae family | −0.13 ± 0.006 | 0.03 | 0.01 ± 0.006 | 0.04 | — | — |
| U. m. of Ruminococcaceae family | 0.005 ± 0.002 | 0.02 | — | — | — | — |
| U. m. of Clostridia class | — | — | — | — | 0.000003 ± 0.000002 | 0.05 |
| U. m. of Erysipelotrichiaceae family 1 | — | — | — | — | −0.0007 ± 0.00004 | 0.05 |
| U. m. of Erysipelotrichiaceae family 2 | — | — | — | — | 0.00004 ± 0.00001 | <0.001 |
| U. m. of A0839 family | 0.0001 ± 0.00004 | 0.01 | — | — | — | — |
| U. m. of Desulfovibrionaceae family | 0.000001 ± 0.0000001 | 0.01 | — | — | — | — |
| U. m. of Succinivibrionaceae family | −0.000006 ± 0.0000003 | 0.05 | — | — | — | — |
| Victivallis | 0.00006 ± 0.00003 | 0.04 | — | — | — | — |
U. m. = Unclassified member; SE = Standard Error.
p* = Multivariate linear regression models adjusted for age, sex, Rockwood Clinical Frailty Scale, CIRS Comorbidity Score and length of antibiotic exposure.
p** = Multivariate linear regression models adjusted for age, sex, number of drugs, CIRS Comorbidity Score and length of antibiotic exposure.
p*** = Multivariate linear regression models adjusted for age, sex, number of drugs, Rockwood Clinical Frailty Scale and length of antibiotic exposure.