Table 4.
Association of the relative abundance of single gut bacteria with specific drug classes in hospitalized patients. Significant correlations between relative abundance of specific taxa of gut microbiota, identified by 16S rRNA microbial profiling analyses, and exposure to specific drugs classes at multivariate linear regression models. Taxa whose relative abundance was not significantly correlated with any specific drug treatment considered in the analysis (diuretics, proton-pump inhibitors, neuroleptics, antidepressants, acetaminophen, antinflammatory drugs, antihypertensive and lipid-lowering drugs) are not shown.
| Taxa | Antidepressants | Antipsychotics | PPIs | |||
|---|---|---|---|---|---|---|
| Beta ± SE | p* | Beta ± SE | p* | Beta ± SE | p* | |
| Asteroleplasma | 0.0007 ± 0.00004 | 0.04 | — | — | — | — |
| Helicobacter | 0.003 ± 0.001 | 0.04 | — | — | — | — |
| Marinilactibacillus | 0.0002 ± 0.00008 | 0.03 | — | — | — | — |
| Prevotella | — | — | 0.04 ± 0.01 | 0.02 | — | — |
| U. m. of Bacilli class | 0.0001 ± 0.000009 | 0.04 | — | — | — | — |
| U. m. of Desulfovibrionaceae family | — | — | 0.000007 ± 0.000002 | 0.005 | 0.00001 ± 0.0000001 | 0.01 |
| U. m. of Succinivibrionaceae family | 0.00004 ± 0.00009 | 0.04 | — | — | — | — |
| Victivallis | — | — | 0.0002 ± 0.0001 | 0.04 | 0.0002 ± 0.0001 | 0.04 |
U. m. = Unclassified member; SE = Standard Error; PPIs = Proton Pump Inhibitors.
p* = Multivariate linear regression models adjusted for age, sex, number of drugs, Rockwood Clinical Frailty Scale, CIRS Comorbidity Score, length of antibiotic exposure and other drug classes.