Table 1.
Basic characteristics of the patients with PBC.
| All patients | Female | Male | Female vs. Male | |
|---|---|---|---|---|
| Total number | n = 1200a | n = 1060 | n = 139 | female: male = 7.63:1 |
| Age of onset (mean years ± SD) | 57 ± 12 | 57 ± 12 | 60 ± 11 | ns |
| Liver biopsy | ||||
| Scheuer 0 | 9/808 (1.1%) | 8/714 (1.1%) | 1/94 (1.1%) | ns |
| Scheuer 1 | 424/808 (52.5%) | 376/714 (52.7%) | 48/94 (51.1%) | ns |
| Scheuer 2 | 223/808 (27.6%) | 197/714 (27.6%) | 26/94 (27.7%) | ns |
| Scheuer 3 | 80/808 (9.9%) | 68/714 (9.5%) | 12/94 (12.8%) | ns |
| Scheuer 4 | 72/808 (8.9%) | 65/714 (9.1%) | 7/94 (7.4%) | ns |
| Outcome | ||||
| hepatocellular carcinoma | 22/1043 (2.1%) | 17/922 (1.8%) | 5/121 (4.1%) | ns |
| liver transplantation | 112/1199 (9.4%) | 101/1060 (9.5%) | 12/139 (8.6%) | ns |
| fatal hepatic failure | 8/1199 (0.7%) | 5/1060 (0.5%) | 3/139 (2.2%) | ns |
| Clinical stage at latest evaluation | ||||
| I | 813/1136 (71.6%) | 725/1006 (72.1%) | 88/130 (67.7%) | ns |
| II | 188/1136 (16.5%) | 163/1006 (16.2%) | 25/130 (19.2%) | ns |
| III | 135/1136 (11.9%) | 118/1006 (11.7%) | 17/130 (13.1%) | ns |
| Concomitant diseases | ||||
| Sjögren’s syndrome | 177/1043 (17.0%) | 169/922 (18.3%) | 8/121 (6.6%) | OR = 3.17, p = 0.0013 |
| systemic sclerosisb | 49/1043 (4.7%) | 47/922 (5.1%) | 2/121 (1.7%) | ns |
| Hashimoto’s thyroiditis | 102/1043 (9.8%) | 96/922 (10.4%) | 6/121 (5.0%) | ns (OR = 2.23, p = 0.058) |
| autoimmune hepatitis | 82/1043 (7.9%) | 76/922 (8.2%) | 6/121 (5.0%) | ns |
| Raynaud’s phenomenon | 32/1043 (3.1%) | 31/922 (3.4%) | 1/121 (0.8%) | ns |
| rheumatoid arthritis | 44/1043 (4.2%) | 43/922 (4.7%) | 1/121 (0.8%) | OR = 5.87, p = 0.0485 |
| Autoantibodies | ||||
| AMA | 956/1085 (88.1%) | 839/960 (87.4%) | 117/125 (93.6%) | OR = 0.47, p = 0.0439 |
| ANA | 752/1042 (72.2%) | 693/926 (74.8%) | 59/116 (50.9%) | OR = 2.87, p = 5.65 × 10−8 |
| gp210 | 331/1134 (29.2%) | 290/1003 (28.9%) | 41/131 (31.3%) | ns |
| CENP-B | 324/1166 (27.8%) | 302/1031 (29.3%) | 22/135 (16.3%) | OR = 2.13, p = 0.00153 |
| SS-A | 178/1166 (15.3%) | 166/1031 (16.1%) | 12/135 (8.9%) | OR = 1.97, p = 0.0285 |
The prevalence of complications and autoantibodies was compared between female and male patients with PBC; significantly increased number and frequency were highlighted in bold. ns: not significant.
aThere are three patients whose information about sex, age and clinical symptoms was not available.
bIncluding limited cutaneous systemic sclerosis (also known as CREST).