Table 3.
Carrier status for HLA-DRB1-DQB1 haplotypes consisting of risk/protective alleles in PBC patients and controls.
| DRB1-DQB1 haplotype | PBC (n = 1199) | Controls (n = 1193) | Odds ratio (95% CI) | p value | ||
|---|---|---|---|---|---|---|
| (A) DRB1*08:03 and/or DQB1*06:01 | ||||||
| DRB1*08:03-DQB1*06:01 | 278 | (23.2%) | 174 | (14.6%) | 1.77 (1.43–2.18) | 7.82 × 10 −8 |
| DRB1*08:03-not (DQB1*06:01) | 4 | (0.3%) | 4 | (0.3%) | 1.33 (0.42–4.21) | 0.62 |
| not (DRB1*08:03)-DQB1*06:01 | 242 | (20.2%) | 228 | (19.1%) | 1.11 (0.92–1.34) | 0.28 |
| (B) DRB1*13:02 and/or DQB1*06:04 | ||||||
| DRB1*13:02-DQB1*06:04 | 36 | (3.0%) | 169 | (14.2%) | 0.19 (0.13–0.27) | 1.84 × 10 −22 |
| DRB1*13:02- not (DQB1*06:04) | 11 | (0.9%) | 6 | (0.6%) | 1.50 (0.58–3.88) | 0.40 |
| not (DRB1*13:02)-DQB1*06:04 | 1 | (0.1%) | 2 | (0.2%) | 0.47 (0.04–5.24) | 0.53 |
| (C) DRB1*14:03 and/or DQB1*03:01 | ||||||
| DRB1*14:03-DQB1*03:01 | 7 | (0.6%) | 32 | (2.7%) | 0.21 (0.09–0.49) | 5.10 × 10 −5 |
| DRB1*14:03- not (DQB1*03:01) | 0 | (0.0%) | 0 | (0.0%) | — | — |
| not (DRB1*14:03)-DQB1*03:01 | 137 | (11.4%) | 224 | (18.8%) | 0.54 (0.43–0.68) | 8.54 × 10 −8 |
| (D) DRB1*04:05 and/or DQB1*04:01 | ||||||
| DRB1*04:05-DQB1*04:01 | 373 | (31.1%) | 277 | (23.2%) | 1.49 (1.24–1.79) | 1.44 × 10 −5 |
| DRB1*04:05- not (DQB1*04:01) | 17 | (1.4%) | 15 | (1.3%) | 0.99 (0.55–1.79) | 0.98 |
| not (DRB1*04:05)-DQB1*04:01 | 5 | (0.4%) | 2 | (0.2%) | 1.59 (0.38–6.65) | 0.53 |
Haplotypes composed of given DRB1 and/or DQB1 alleles were compared. The statistical tests reaching significance (p < 0.05) were highlighted in bold.