Table 4.
Effect of the risk/protective DRB1/DQB1 alleles on the presence/absence of another risk/protective DRB1/DQB1 allele.
| Effect of HLA allele | HLA background | |
|---|---|---|
| Present | Absent | |
| Effect of DRB1*08:03 in the presence/absence of DQB1*06:04 | ||
| Frequencies in subset of patients/controls | 5.4%/4.7% | 24.1%/16.6% |
| Odds ratio (95% CI), p | 1.16 (0.24–5.74), p = 0.85 | 1.59 (1.29–1.97), p = 1.70 × 10 −5 |
| Effect of DQB1*06:04 in the presence/absence of DRB1*08:03 | ||
| Frequencies in subset of patients/controls | 0.7%/4.5% | 3.8%/16.1% |
| Odds ratio (95% CI), p | 0.15 (0.03–0.73), p = 0.0068 | 0.21 (0.14–0.30), p = 8.16 × 10 −19 |
The effect of the most significant risk/protective DRB1 and DQB1 alleles was evaluated by comparing the frequencies between patients with PBC and control population in the presence/absence of another risk/protective allele. Significant differences (p < 0.05) in the comparisons are highlighted in bold.