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. 2017 Sep 11;7:11170. doi: 10.1038/s41598-017-11679-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Retinal imaging of a patient with NSRP due to mutations in USH2A compared to a healthy individual. Color fundus photo of the posterior pole of a healthy individual (a) compared to a patient (P18) with NSRP (b), showing extensive intraretinal pigment migration observed temporally. SW-AF imaging reveals a characteristic foveal autofluorescent ring in P18 (d), which is absent in the healthy individual (c). SD-OCT of a healthy individual shows intact retinal structure (e, top) compared to P18 (e, bottom). Note the thinning of outer retinal layers in the periphery and the sparing of the ellipsoid zone in the central macula in P18.