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. 2017 Sep 11;8:499. doi: 10.1038/s41467-017-00547-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Cas5 governs cell cycle dynamics under basal and cell wall stress conditions. a Circos plot depicting the number of genes with increased (red) and decreased (blue) RNA PolII binding in the cas5∆/cas5∆ mutant whose normal expression in the wild-type peaks at the indicated cell cycle stage. b Cas5 is required for the decreased PolII binding at genes encoding MCM complex members and CDC6 in response to caspofungin. Histogram showing the PolII ChIP-Seq signal for the indicated genes encoding MCM complex components in response to caspofungin treatment. Error bars represent standard deviation (s.d.) from the mean of duplicate samples. c Downregulation of MCM2 and MCM3 in response to caspofungin depends on Cas5. Transcript levels were monitored by qRT-PCR and normalized to TEF1. Error bars represent s.d. from the mean of triplicate samples. Significance was measured with an unpaired t test in GraphPad Prism (*P < 0.05). d Circos plots illustrating the number of genes with increased (red) or decreased (blue) PolII binding in response to caspofungin (CF) in wild-type and cas5∆/cas5∆ strains for genes whose expression is regulated throughout the cell cycle