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. 2017 Sep 11;7:11144. doi: 10.1038/s41598-017-11661-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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ATM deficiency increases chromosomal alterations in pancreatic cancer cells. (A) Representative SKY images showing the chromosomal alterations of low-passage KC (121.3) and KCATMΔΔ (161.3) cells from both, the primary tumor [PDAC] and a corresponding liver metastasis [LM]). (B) Summary of SKY results showing that breakage and non-clonal chromosomal alterations are more frequent in KCATMΔΔ cultures than in KC cultures. (C) SKY data show that clonal alterations unique to liver metastases are more numerous in KCATMΔΔ tumor cells than in KC tumor cells.