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. 2017 Sep 11;7:11228. doi: 10.1038/s41598-017-10541-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Group difference in insular activity correlated with subjective value of probabilistic loss in the risk aversion task. SA: Suicide attempters, ND: Nonsuicidal depressed patients, HC: Healthy controls. A one-way ANOVA across groups (p < 0.05, small volume corrected) revealed a significant overall group difference, and in particular, a significant difference between the suicide attempters and healthy controls (p < 0.001, post hoc Tukey’s test). Left insula activity was significantly correlated with subjective loss in the suicide attempters only, such that activity decreased with size of loss (p < 0.01, one-sample t test). Mean ± S.E.M.