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. 2017 Sep 11;7:11152. doi: 10.1038/s41598-017-11606-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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WIN but not URB597 impaired the induction of the LTP in naïve rats. In (a) representative DG field potentials in vehicle, WIN (2 mg/kg) and URB597 (1 mg/kg) treated rats at the baseline (dark traces) and 10 min after HFS (light traces). Scale bar = 3 mV and 5 ms. (b,d,f). Time course changes of the average normalized (against baseline) population spike (PS) amplitude before and after HSF-induced LTP. Drugs were administered i.p. at the arrows. The first arrow refers to AM251 injection or its vehicle, while the second arrow refers to either WIN or URB597 administrations or their vehicle. Each point represents the mean ± S.E.M. expressed as a percentage of baseline values. (c,e,g). A combined plot of the averages of the PS amplitude after HFS. Each group is presented as the mean ± SEM. One-way ANOVA followed by Bonferroni’s post-hoc test; *p < 0.05, **p < 0.01 vs vehicle group; ^$$p < 0.01, ^$p < 0.05 vs WIN 0.5 mg/kg; ^#p < 0.05. vs AM251 + WIN 2 mg/kg; °p < 0.05 vs AM251.