Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Sep 11;7:11152. doi: 10.1038/s41598-017-11606-1

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

URB597 but not WIN reverted the seizure-induced LTP impairment in rats subjected to MDA acute kindling. In (a) representative field potentials at the baseline (dark traces) and 5 min after HFS (light traces) recorded in naïve rat (vehicle) and in rats subjected to MDA kindling in presence of vehicle (Vehicle-MDA), WIN (2 mg/kg) (WIN-MDA) and URB597 (1 mg/kg) (URB597-MDA). Scale bar = 3 mV and 5 ms. Dot plots (means ± SEM expressed as a percentage of baseline values) of relative population spike (PS) amplitudes from 10 min before to 120 min after HFS in control and MDA group (b) and in Vehicle post-MDA, WIN (2 mg/kg) post-MDA and URB597 (1 mg/kg) post-MDA groups (d). HFS was delivered at time point ‘0.’ (c,e). A combined plot of the averages of the PS amplitude after HFS. Each group is presented as the mean ± SEM. One-way ANOVA followed by Bonferroni’s post-hoc test; **p < 0.01 vs vehicle group; ^#p < 0.05 vs vehicle-MDA group; °p < 0.05. vs WIN-MDA group.