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. 2017 Sep 11;7:11152. doi: 10.1038/s41598-017-11606-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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WIN, but not URB597 negatively affected STP in naïve rats. In (a) representative field potentials after paired stimulations 20, 25, 110 and 600 ms apart at the pre-drug condition (dark traces) and after drug administration (coloured traces) in vehicle, WIN (2 mg/kg) and URB597 (1 mg/kg) treated rats. Scale bar = 2 mV and 5 ms. Graphs represents the mean ratios at each interpulse interval (IPI) before (pre-drug) and after administration of drugs. Administration of vehicle (b), URB597 (d), AM251 (e) and AM251 + URB597 (g) had no effect on STP, whereas WIN selectively impaired paired pulse facilitation (c). The effect of WIN was abolished by pre-administration of AM251 (f). One-way ANOVA for repeated measures followed by Bonferroni’s post hoc test; *p < 0.05 versus control (pre-drug) group.