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. 2017 Sep 11;7:11152. doi: 10.1038/s41598-017-11606-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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URB597, but not WIN restored paired pulse facilitation in rats subjected to MDA acute kindling. (a) Representative DG field potential responses after paired stimulations 20, 25, 110 and 600 ms apart in vehicle, WIN 2 mg/kg, and URB597 1 mg/kg before MDA induction (dark traces) and at the end of 4 hours stimulation at frame 24 (coloured traces). Scale bar = 2 mV and 5 ms. MDA acute kindling impaired paired pulse facilitation in vehicle (b), WIN (c) and AM251 (e) and AM251 + WIN (f) groups. Conversely, administration of URB597 was able to prevent the MDA-induced alteration of paired pulse facilitation (d) and this effect was blocked by the pre-administration of AM251 (g). Drugs were injected one hour after MDA induction at stimulus n. 6. Graphs represents the mean ratios at each interpulse interval before (pre-drug) and after administration of drugs. One-way ANOVA for repeated measures followed by Bonferroni’s post hoc test; *p < 0.05 and **p < 0.01 versus pre-MDA condition.