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. 2017 Sep 11;7:11152. doi: 10.1038/s41598-017-11606-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of peripheral administration of cannabinoid compounds on the basal synaptic activity and cellular excitability of dentate granular cells to perforant path (PP) stimulation with increasing stimulation strength. (a) Representative DG field potential responses obtained with stimulation intensities ranging from 100 through 1000 μA, recorded in naïve (pre drug) condition and after the administration of vehicle, WIN and URB597. Scale bar = 2 mV and 5 ms. Graphs were obtained by plotting fEPSP slope against PS amplitude for each stimulus strength in pre-drug condition and after drug administration. WIN, URB597 and AM251 did not affect the fEPSP slope and PS amplitude recorded in naïve rats (b–g).