Table 1.
Pharmacokinetic parameters for amphetamine based on compartmental modeling.
| Dose | N | k01 (1/h) | λ (1/h) | Vd (L) | Cmax (ng/mL) | tlag | tmax (h) | t1/2 (h) | AUC∞ (ng ⋅ h/ml_) | CL/F (L/h) |
|---|---|---|---|---|---|---|---|---|---|---|
| D-amphetamine | 23 geometric mean (95% CI) | 1.3 (0.84–1.95) | 0.088 (0.077–0.101) | 195 (172–220) | 120 (108–133) | 0.8 (0.6–1.0) | 3.3 (2.7–3.9) | 7.9 (6.9–9.1) | 1727 (1540–1935) | 17 (15–19) |
| Range | 0.41–17 | 0.046–0.162 | 113–375 | 77–181 | 0.3–2.0 | 0.9–5.9 | 4.3–15 | 1116–3463 | 9–27 | |
| Lisdexamfetamine | 24 geometric mean (95% CI) | 0.78 (0.63–0.98) | 0.088 (0.078–0.098) | 186 (166–209) | 118 (108–128) | 1.5 (1.3–1.7)∗∗∗ | 4.6 (4.1–5.2)∗∗∗ | 7.9 (7.1–8.9) | 1817 (1637–2017) | 16 (15–18) |
| Range | 0.25–1.9 | 0.055–0.148 | 88–266 | 83–174 | 0.8–2.4 | 2.5–8.4 | 4.7–13 | 1087–3031 | 10–27 | |
AUC8, area under the plasma concentration-time curve from time zero to infinity; Cmax, estimated maximum plasma concentration; t1/2, estimated plasma elimination half -life; tlag, lag time or time; tmax, estimated time to reach Cmax; k01, first-order absorption coefficient; λ, first order elimination coefficient; Vd, volume of distribution. ∗∗∗P < 0.001 compared with D-amphetamine (two-sided T-tests).