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. 2017 Sep 7;8:1111. doi: 10.3389/fimmu.2017.01111

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Copyright © 2017 Ocón, Pan, Dinh, Chen, Ballet, Bscheider, Habtezion, Tu, Zabel and Butcher.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Perinatal pDETC chemotax to GPR15L in a GPR15-dependent manner. (A) Gating strategy and GPR15 expression of pDETC and non-pDETC in day 0 GPR15-gfp reporter mice. (B) Percentage of pDETC and non-pDETC cells that migrated to the bottom chamber. (C) Checkerboard experiment; % migration of pDETC. (D) Effect of pertussis toxin on the GPR15L-induced pDETC migration, expressed as % migration. (E) Effect of the GPR15 deficiency in the CXCL12 and GPR15L-induced migration of pDETC. Non-pDETC migrated to CXCL12 (not shown). Data pooled from two independent experiments are presented as mean ± SEM. ⁺P < 0.05 vs NC, *P < 0.05 vs other cell subset under the same experimental condition. DETC, dendritic epidermal T cells; NC, no chemokine; gfp, green fluorescent protein.