Table III.

Univariate analysis of prognostic factors influencing OS and DFS.

	OS			DFS
Characteristic	HR	95% CI	P-value	HR	95% CI	P-value
Age, years (≥60 or <60)	1.634	1.093–2.444	0.016	1.038	0.675–1.597	0.864
Sex (male or female)	0.935	0.620–1.411	0.749	0.854	0.552–1.321	0.477
Smoking index (≥400 or <400)	1.243	0.831–1.858	0.288	0.894	0.579–1.381	0.613
Lymph node metastasis (yes or no)	1.905	1.243–2.918	0.003	1.620	1.035–2.537	0.033
TNM stage (I–II or IIIA)	1.745	1.156–2.635	0.008	1.878	1.215–2.905	0.005
Operative approach	1.199	0.744–1.933	0.510	1.118	0.642–1.946	0.511
Albumin (≥49.5 or <49.5 g/dl)	2.078	1.076–4.010	0.026	1.978	0.952–4.110	0.062
WBC count (≥5.6 or <5.6 ×109 cells/l)	1.261	0.799–1.992	0.318	1.118	0.692–1.808	0.647
NLR (≥2.16 or <2.16)	1.724	1.150–2.584	0.008	1.551	1.005–2.395	0.045
PLR (≥145 or <145)	2.188	1.430–3.349	<0.001	1.818	1.146–2.884	0.010
PLT (≥289 or <289×109 cells/l)	2.222	1.426–3.461	<0.001	1.635	1.012–2.642	0.042
FBG (≥4 or <4 g/l)	2.131	1.417–3.206	<0.001	1.875	1.202–2.925	0.005
CO-NPF (≥2 or <2)	2.187	1.451–3.295	<0.001	2.156	1.380–3.370	0.001

Operative approaches were local tumor resection, pulmonary lobectomy or pneumonectomy. TNM, tumor-node-metastasis; HR, hazard ratio; CI, confidence interval; NLR, neutrophil to lymphocyte ratio; PLR, platelet to lymphocyte ratio; PLT, platelet; FBG, fibrinogen; CO-NPF, combination of NLR, PLR, FBG and PLT; WBC, white blood cell; OS, overall survival; DFS, disease-free survival.