Table 3.

Hazard ratios of specific psychiatric disorders among children born to mothers with continuous antidepressant use, compared with mothers with discontinuous antidepressant use (n=47 639)

Antidepressant use during pregnancy*	Cases	No	Person years	Crude hazard ratio	Adjusted hazard ratio (95% CI)†
Autism spectrum disorder:
Antidepressant discontinuation group	257	30 079	2.2×105	1	1 (reference)
Antidepressant continuation group	165	17 560	1.2×105	1.32	1.23 (1.01 to 1.51)
Mood disorder:
Antidepressant discontinuation group	26	30 079	2.2×105	1	1 (reference)
Antidepressant continuation group	27	17 560	1.2×105	2.72	2.76 (1.59 to 4.78)
Neurotic, stress related, and somatoform disorder:
Antidepressant discontinuation group	276	30 079	2.2×105	1	1 (reference)
Antidepressant continuation group	249	17 560	1.2×105	1.92	1.62 (1.36 to 1.94)
Behavioural and emotional disorder:
Antidepressant discontinuation group	789	30 079	2.2×105	1	1 (reference
Antidepressant continuation group	470	17 560	1.2×105	1.24	1.13 (1.01 to 1.27)
Mental retardation:
Antidepressant discontinuation group	53	30 079	2.2×105	1	1 (reference)
Antidepressant continuation group	33	17 560	1.2×105	1.25	1.21 (0.78 to 1.90)

*Antidepressant discontinuation group=children whose mothers used antidepressants before but not during pregnancy; antidepressant continuation group=children whose mothers used antidepressants both before and during pregnancy.

†Adjusted for maternal age at delivery, primiparity, maternal psychiatric history at delivery, inpatient and outpatient psychiatric treatment from 2 years before pregnancy until delivery, dispensing of other psychotropic prescriptions during pregnancy, dispensing of antiepileptic prescriptions during pregnancy, number of non-psychiatric hospital visits during pregnancy, smoking during pregnancy, place of residence, marital status, highest education, income, calendar year of delivery, and paternal psychiatric history at time of delivery.