Fig. 5.

Semi-quantitative analysis of histopathology. Mice were exposed to silica or vehicle weekly for the first four weeks, while receiving IMP or PBS by osmotic pump for entire six week duration. Multiparametric scoring of H&E-stained lung tissue was completed using an ordinal scale ranging from no significant pathology (score: 0) to severe pathology (score: 5). a Alveolar proteinosis. b Alveolitis including mixed inflammatory cell infiltrates, microgranulomas, and associated interstitial fibrosis. c Perivascular/peribronchiolar lymphoid aggregates. d Type II alveolar epithelial cell hyperplasia. Tissue was scored from n ≥ 3 mice per treatment condition