Fig. 7.

Collagen staining from IMP co-administration study. Mice were exposed to silica or vehicle weekly for the first four weeks, while receiving IMP or PBS by osmotic pump for entire six week duration. Light photomicrographs are lung sections stained for increased collagen (red chromagen; arrows) with hematoxylin counterstain from mice treated with (a) vehicle, (b) IMP, (c) silica, and (d) silica + IMP. Silica treatment resulted in a mild increase in collagen associated with microgranulomas (asterisks), which was reduced by IMP. Abbreviation: a = alveolar parenchyma. Tissue was observed from n ≥ 3 mice per treatment condition